Severe craniocerebral injury complicated with pulmonary infection
Conditions
Interventions
observation group:Add vitamin C injection and glutathione for injection + conventional therapy
control group:Conventional therapy
Sponsors
The 903rd Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
16 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for patients with severe craniocerebral injury: (1) All patients had a clear history of trauma, with a certain degree of coma, which was confirmed by imaging; (2) Patients aged 16-60 years; (3) GCS score 72h; (5) None of the patients had pulmonary infection on admission. 2. Inclusion criteria for pulmonary infection: Patients met the diagnostic criteria of nosocomial infection during hospitalization, and ventilator-associated pneumonia occurred 48h after mechanical ventilation or 72h after offline.
Exclusion criteria
Exclusion criteria: Previous epilepsy, cerebral infarction, brain tumor, pulmonary tuberculosis, lung tumor and other major organic lesions of the brain and lung.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| white blood cell;hypersensitivity protein;neutrophils;blood pH;blood oxygen saturation;arterial partial pressure of oxygen;arterial carbon dioxide partial pressure;malondialdehyde;superoxide dismutase;lipid peroxide;total antioxidant capacity;myeloperoxidase; | — |
Countries
China
Contacts
Public ContactWang Xiaoxia
The 903rd Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army
Outcome results
None listed