None listed
Conditions
Interventions
Group 1 :metahydroxylamine infusion from anesthesia induction to the end of surgery
Group 2:phenylephrine infusion from anesthesia induction to the end of surgery
Sponsors
The First Affiliated Hospital of Suzhou University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Elderly patients undergoing elective gastrointestinal surgery (operation time >= 1.5 h, aged >= 65 years), ASA grade I-III.
Exclusion criteria
Exclusion criteria: 1. Severe liver and kidney insufficiency; 2. Previous history of hyperthyroidism, pheochromocytoma, severe cardiovascular and cerebrovascular diseases, hemodynamic instability, and grade 3 hypertension; 3. Chronic obstructive pulmonary disease requires the use of bronchodilators and pulmonary hypertension; 4. Recently used tricyclic antidepressants or monoamine oxidase inhibitors; 5. The patient refuses to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| total vessel density, TVD;perfused vessel density, PVD;proportion of perfused vessels, PPV;microcirculatory flow index, MFI;lactate;hemoglobin; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood pressure;heart rate;postoperative hospital stay;postoperative complications; | — |
Countries
China
Contacts
Public ContactJi Fuhai
The First Affiliated Hospital of Suzhou University
Outcome results
None listed