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Effect of Clostridium butyricum supplementation on postpartum depression and its mechanism

Effect of Clostridium butyricum supplementation on postpartum depression and its mechanism

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200060398
Enrollment
Unknown
Registered
2022-05-30
Start date
2022-05-19
Completion date
Unknown
Last updated
2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postpartum depression

Interventions

Group 1 :Oral clostridium butyricum + psychotherapy
Group 2:Psychotherapy

Sponsors

Women's Hospital School of Medicine Zhejiang University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 49 Years

Inclusion criteria

Inclusion criteria: 1. Inclusion criteria for patients with postpartum depression: (1) Age 20-49 years old; (2) Patients diagnosed with PPD by a psychiatrist; onset within 3 months after delivery; Edinburgh Postpartum Depression Scale (EDPS) score range >= 13; (3) Sign a written informed consent; 2. Inclusion criteria for healthy subjects: (1) Age between 20-49 years old; (2) Within 3 months after delivery; (3) Postpartum health examination (blood routine, liver and kidney function, electrocardiogram) is normal, without obvious discomfort; (4) EDPS score < 13; (5) Sign the written informed consent.

Exclusion criteria

Exclusion criteria: 1. Pregnancy; 2. Have a history of serious medical diseases, mental diseases and central nervous system diseases; 3. Suffering from severe obstetric complications and complications; 4. Changes in eating habits or history of antibiotic use within 1 month before sampling; 5. Those taking other antipsychotic drugs.

Design outcomes

Primary

MeasureTime frame
Edinburgh Depression Scale;Zung Anxiety Self-Rating Scale;

Countries

China

Contacts

Public ContactXinzhong Chen

Women's Hospital School of Medicine Zhejiang University

chenxinz@zju.edu.cn+86 13575738058

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026