Major Depressive Disorder
Conditions
Interventions
Group 1 :Psychological intervention of 'displacement therapy'
Group 2:Treat as usual during the 8-week waiting interval, and receive the same intervention as the intervention group
Sponsors
Institute of Psychology, Chinese Academy of Sciences
Eligibility
Sex/Gender
All
Age
19 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Age 19-35 years old; 2. Have fluent reading and writing skills to ensure that they can understand the instructions; 3. Sign the informed consent; 4. Suitable for MRI examination: (1) No metal or electronic implants in the body (such as metal cochlear implants or pacemakers); (2) No prosthesis (such as dentures, metal braces, etc.); (3) No hair dyeing, tattooing or tattooing; (4) No claustrophobia; (5) No severe spondylosis; (6) No traumatic brain injury; 5. Patients with clinical depression: all patients meet the ICD-10 diagnosis of major depressive disorder and are receiving antidepressant treatment; 6. PHQ-9 score above 10 points, HAMD score above 10 points; 7. The patient participated in this study and obtained the verbal informed consent of the psychiatrist; 8. Right-handed, with normal vision or corrected vision; 9. Have an Android phone (currently our electronic bracelet and APP only support Android 6.0 or above); 10. Have a strong motivation to support scientific research on depression, be able to cooperate with 8-week psychological intervention, psychological testing and brain scanning procedures, and be willing to participate in 10-year follow-up research.
Exclusion criteria
Exclusion criteria: 1. Suffering from diseases that may affect the ability to complete the experiment (such as alexithymia); 2. The brain has been injured, or has suffered a severe blow to the head and has been unconscious for more than 10 minutes; 3. Severe impairment of vision/hearing or hand movement, which makes it impossible to complete the experiment or understand the requirements of the experiment; 4. Pregnant/lactating women; 5. Contraindications for magnetic resonance examination (claustrophobia or metal or electronic implants in the body); 6. Had psychotic symptoms; 7. Patients with mixed depression, acute depression, bipolar disorder, endogenous depression, and treatment-resistant depression; 8. Substance abuse or alcohol abuse; 9. The interview revealed the presence of dangerous suicidal ideation (specific suicide plans and intentions).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| depressive symptoms;anxiety symptoms;positive and negative moods;ruminative response;subjective distress;pleasure experience;cognitive flexibility; | — |
Secondary
| Measure | Time frame |
|---|---|
| childhood trauma;life events and difficulties;uncertainty intolerance;subjective cognitive capacity;behavioural inhibition/activation (trait);mental flexibility;insomnia severity;mental state;emotional working memory;behavioural inhibition (reaction time and accuracy);thinking stypes; | — |
Countries
China
Contacts
Public ContactChaogan Yan
Institute of Psychology, Chinese Academy of Sciences
Outcome results
None listed