Sepsis-associated encephalopathy
Conditions
Interventions
None listed
Sponsors
Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age > 18 years old; 2. The diagnosis conforms to the international diagnostic standard of sepsis (Sepsis 3.0).
Exclusion criteria
Exclusion criteria: 1. Stay in ICU for less than 24 hours; 2. Patients with primary craniocerebral injury (ischemic or hemorrhagic cerebrovascular events, tumors); 3. Patients with intracranial infection; 4. Patients supported by intra-aortic balloon counterpulsation or extracorporeal membrane oxygenation; 5. Patients with severe carotid or intracranial artery stenosis (> 70%); 6. TCCD silent window (cerebral blood flow signal cannot be obtained); 7. Patients with severe visual or hearing impairments who cannot be evaluated by CAM-ICU; 8. Patients with delirium or disturbance of consciousness before being transferred to ICU.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Middle cerebral artery pulse index;Local brain tissue oxygen saturation;CNS specific protein (S100-ß);Blood pressure;Oxygenation index;Potential Of Hydrogen, PH;Arterial lactic acid;Total bilirubin;Serum creatinine;Procalcitonin, PCT;Interleukin -6; | — |
Countries
China
Contacts
Public ContactYing Liu
The Affiliated Hospital of Guizhou Medical University
Outcome results
None listed