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Effects of esketamine on analgesia and postnatal depression after cesarean section and research on relevant mechanisms

Effects of esketamine on analgesia and postnatal depression after cesarean section and research on relevant mechanisms

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200060387
Enrollment
Unknown
Registered
2022-05-30
Start date
2022-06-10
Completion date
Unknown
Last updated
2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postpartum depression

Interventions

Group 1:The analgesic formula was added with esesketamine 0.2 mg/kg
Group 2:The analgesic formula was added with esesketamine 0.8 mg/kg
Group 3:The analgesic formula was provided without esteketamine

Sponsors

The Affiliated Jiangning Hospital of Nanjing Medical University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
22 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1. Single-term pregnant women; 2. Age 22-35 years old; 3. ASA II level; 4. Routine inspection is normal.

Exclusion criteria

Exclusion criteria: 1. Pregnancy complications; 2. Improper fetal position, breech position, etc.; 3. Combined with vital organ insufficiency; 4. Organic or drug-induced depression before operation; 5. Mental disorder, mental retardation and other diseases before operation.

Design outcomes

Primary

MeasureTime frame
Postoperative pain score;Postoperative sufentanil consumption;Postoperative maternal depression occurred;Perioperative serum leptin, norepinephrine, and epinephrine levels;

Secondary

MeasureTime frame
Postoperative adverse effects;

Countries

China

Contacts

Public ContactWei Wang

The Affiliated Jiangning Hospital of Nanjing Medical University

wangwei2024@163.com+86 13851885625

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 8, 2026