frailty
Conditions
Interventions
Group 1:
Group 2:
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age over 65 years old, gender is not limited; 2. The ASA classification is II, III; 3. BMI 18-28 kg/m2; 4. Patients receiving examination or treatment outside the operating room; 5. Score on the Simple Frailty Questionnaire (FRAIL) and/or Modified Frailty Index (mFI) >= 3 points; 6. Patients voluntarily participated in this study and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic or contraindicated to benzodiazepines, opioids, propofol and other drugs and their drug components; 2. Acute heart failure; unstable angina; myocardial infarction within 6 months before screening; resting ECG heart rate = 470 ms, female >= 480 ms; grade III atrioventricular stagnation; severe heart rhythm abnormality; moderate to severe heart valve disease; 3. Patients with severe respiratory diseases (acute respiratory infection, acute exacerbation of chronic obstructive pulmonary disease, uncontrolled asthma, etc.); 4. Patients who have not received formal antihypertensive treatment or poorly controlled blood pressure; 5. Craniocerebral injury, possible intracranial hypertension, cerebral aneurysm, history of cerebrovascular accident, and central nervous system disease; 6. Suffering from psychiatric diseases (schizophrenia, mania, bipolar disorder, insanity, etc.) and long-term use of psychotropic drugs and cognitive dysfunction; 7. Other conditions judged by the researchers to be unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hypotension; | — |
Secondary
| Measure | Time frame |
|---|---|
| respiratory depression;recovery time;injection pain;bradycardia; | — |
Countries
China
Contacts
Public ContactDan Cheng
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed