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Prothrombin Induced by Vitamin K Absence-II Versus Alpha-fetoprotein in Detection of Both Resectable Hepatocellular Carcinoma and Early Recurrence After Curative Liver Resection: An Observational Cohort Study

Prothrombin Induced by Vitamin K Absence-II Versus Alpha-fetoprotein in Detection of Both Resectable Hepatocellular Carcinoma and Early Recurrence After Curative Liver Resection: An Observational Cohort Study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200060373
Enrollment
Unknown
Registered
2022-05-29
Start date
2022-05-18
Completion date
Unknown
Last updated
2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatocellular carcinoma

Interventions

None listed

Sponsors

The Third Affiliated Hospital of Naval Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
41 Years to 74 Years

Inclusion criteria

Inclusion criteria: Data on consecutive patients who underwent curative resection for HCC between 2014 and 2020 was prospectively collected and reviewed.

Exclusion criteria

Exclusion criteria: 1. With metastatic HCC or HCC combined with bile duct tumor thrombus; 2. Patients who have taken warfarin before surgery; 3. Patients receiving non-radical surgery; 4. Patients without AFP and PIVKA-II test results one week before surgery; 5. Patients who died within 90 days after surgery; 6. Postoperative follow-up of patients who lost contact.

Design outcomes

Primary

MeasureTime frame
AFP and PIVKA-II positivities for patients with HCC;—

Secondary

MeasureTime frame
The rate of early recurrence;—

Countries

China

Contacts

Public ContactTian Yang

Third Affiliated Hospital of Naval Medical University

yangtianehbh@smmu.edu.cn+86 18917015805

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026