Autism spectrum disorders
Conditions
Interventions
Group 1 :
Group 2:
Sponsors
Xi’an Ninth Hospital
Eligibility
Sex/Gender
All
Age
2 Years to 7 Years
Inclusion criteria
Inclusion criteria: 1. Autism Spectrum Disorders (ASD): (1) Meet the diagnostic criteria for autism spectrum disorder in the fifth edition of the American Diagnostic and Statistical Manual of Mental Disorders (DSM-V); (2) The age range is 2-7 years old; (3) Parents (or guardians) voluntarily let children participate in this research and are able to cooperate with the research, and sign the research informed consent; 2. Normal development group (TD): (1) The age range is 2-7 years old; (2) Normal development before and after birth, and no family history of ASD; (3) Parents (or guardians) voluntarily let children participate in this research and are able to cooperate with the research, and sign the research informed consent.
Exclusion criteria
Exclusion criteria: 1. Paticipants with a history of craniotomy; 2. Paticipants who have been installed with cardiac stents, valves and pacemakers; 3. Paticipants with cochlear implants and hearing aids; 4. Paticipants with metallic foreign bodies in the eyeball or various metal implants in the body; 5. Paticipants with history of epilepsy, Tourette syndrome or other brain diseases, such as brain trauma, brain tumor, cerebrovascular disease, encephalitis, cerebral palsy, etc; 6. Paticipants with other diseases that may cause discomfort, such as claustrophobia, severe or recent heart, lung, liver, kidney, gastrointestinal diseases, and acute infectious diseases within one month; 7. There are genetic diseases (such as fragile X syndrome, tuberous sclerosis, phenylketonuria, Rett syndrome, Angelman syndrome, Prader Willi syndrome, intermittent porphyria, etc.); 8. Paticipants with severe allergic history (such as chloral hydrate, etc.); 9. Paticipants with a history of psychotropic drug treatment; 10. Paticipants have taken antibiotics, antifungals, probiotics or performed other gastrointestinal treatments in the last 3 months; 11. There are intestinal organic diseases such as congenital megacolon, intestinal obstruction, intussusception, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal flora;Neurotransmitter;Multidimensional development and behavioral assessment;Brain structure (MRI);Resting state functional magnetic resonance;Intelligence;Metabonomics characteristics of feces; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep condition; | — |
Countries
China
Contacts
Public ContactShuhan Yang
Xi’an Ninth Hospital
Outcome results
None listed