Choledocholithiasis, suppurative cholangitis, bile duct stenosis
Conditions
Interventions
50-59 years group :
Remimazolam tosylate with high dose
60-69 years group :
Remimazolam tosylate with mid-high dose
70-79 years group :
Remimazolam tosylate with mid-low dose
80-89 years group :
Remimazolam tosylate with low dose
Sponsors
The First Affiliated Hospital of USTC (Anhui Provincial Hospital)
Eligibility
Sex/Gender
All
Age
50 Years to 89 Years
Inclusion criteria
Inclusion criteria: 1. 50 years old <= age <= 89 years old; 2. ASA I-III level; 3. BMI 18 kg/m2 - 30 kg/m2; 4. Endoscopic retrograde cholangiopancreatography (ERCP) under general anesthesia is needed in the elective period; 5. Be able to understand and voluntarily sign the informed consent form, and be willing to comply with the requirements of the test plan.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic or contraindicated to benzodiazepines, opioids, propofol, flumazenil, naloxone and other drugs and their drug components; 2. Severe organ dysfunction in the decompensation stage: (1) Severe cardiac insufficiency (LVEF = 160 mmHg, and/or diastolic blood pressure >= 110 mmHg); 4. Uncontrolled diabetes (fasting blood sugar >= 10 mmol/L); 5. Uncontrolled coronary heart disease (history of myocardial infarction in the past 3 months, or unstable angina in the past 1 month, or untreated stable angina); 6. Patients with mental illness or those with a history of alcoholism, opioid allergy or such drug abuse; 7. Emergency surgery subjects; 8. Pregnant or lactating women; 9. Other conditions that the researchers think are not suitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified observer’s assessment of alert, MOAA/S;Bispectral index (BIS) ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure, MAP;Heart rate;Pulse oxygen saturation; | — |
Countries
China
Contacts
Public ContactXu Min
The First Affiliated Hospital of USTC (Anhui Provincial Hospital)
Outcome results
None listed