Climacteric depression
Conditions
Interventions
Group 1:YYSG granule + Frontal Acupuncture
Group 2:YYSG granule + Sham Frontal Acupuncture
Group 3:Frontal Acupuncture + YYSG placebo granules
Group 4:YYSG placebo granule + Sham Frontal Acupuncture
Sponsors
Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
Female
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. 40 years old 10 U/L, serum E2 levels decreased; 3. Depression or depression, sighing, easy to pessimistic, accompanied by upset, sometimes flushing, hot flashes, backache, etc.; 4. Insomnia, dreaminess, mainly manifested as difficulty in falling asleep at night, not deep sleep, early awakening, and difficulty falling back asleep after waking up; 5. The scores of 17 items of Hamilton Depression Scale (HAMD) are all >= 8 points; or the scores of SAS scale and SDS scale are >= 62 points; 6. For menstrual disorders, the thickness range of the subject's B-ultrasound endometrium is 7 mm - 10 mm (including the boundary value); 7. Dark tongue, thin yellow or white fur, stringy and weak pulse.
Exclusion criteria
Exclusion criteria: 1. Used sex hormone therapy, selective estrogen receptor modulators, or aromatase inhibitors, soybean extracts in the past 3 months; 2. Those who have a history of habitual use of antibiotics or have used antibiotics, probiotics, prebiotics, micro-ecological live bacteria preparations; laxatives or other drugs that affect gastrointestinal function in the past 1 month; 3. Participated in phase III-IV clinical research in the past 3 months; 4. Combined with malignant tumors of the breast, digestive tract, and reproductive tract; 5. Pregnant or lactating women; 6. Combined with severe liver, kidney, heart, and brain diseases; gastrointestinal diseases, diabetes, obesity, etc.; 7. Combining other genetic mental diseases such as personal history/family history of mental diseases; 8. Those with damaged skin at the treatment site; 9. Those who are unwilling to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Greene scale;Self-rating Anxiety Scale (SAS);Self-rating Depression Scale (SDS);Hamilton Anxiety Scale, HAMA Scale;Hamilton Depression Scale, HAMD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum sex hormone level;Brain fMRI;Detection of intestinal flora; | — |
Countries
China
Contacts
Public ContactCao Xiaojing
Guangdong Provincial Hospital of Chinese Medicine
Outcome results
None listed