autism spectrum disorder
Conditions
Interventions
Experimental group:Umbilical cord blood mononuclear cells were intravenously transfused
Sponsors
The Second Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
2 Years to 7 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for autism in the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV); 2. Childhood autism rating scale (CARS) >= 30 points; 3. Age 2 to 7 years old, weight 11-27 kg, gender is not limited; 4. No family history of bleeding and coagulation diseases; 5. Did not receive drug treatment that has a greater impact on the immune system, such as glucocorticoids, cytotoxic drugs, etc. before seeing a doctor; 6. No family history of cancer; 7. Agree to carry out post-rehabilitation treatment in the Second Hospital of Hebei Medical University.
Exclusion criteria
Exclusion criteria: 1. Have a history of severe allergic reactions in the past; 2. Any serious mental disorder or other autism spectrum disorder, such as Asperger's syndrome, Rett's syndrome or undefined pervasive developmental disorder; 3. Autism caused by active epilepsy, cerebrovascular disease or traumatic brain injury; 4. Severe heart, lung, liver, and kidney dysfunction: the test results of any of the following items of the subject are > 2 x ULN: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline Phosphatase (ALP), or total bilirubin > ULN (total bilirubin >= 1.5 x ULN if known to have Gilbert syndrome); 5. History of previous stem cell therapy; 6. Serious self-harm; 7. Have a history of syphilis, HIV and hepatitis infectious diseases; 8. Patients who cannot cooperate with follow-up visits.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Childhood Autism Rating Scale (CARS) score; Autism Behavior Checklist, ABC;Social Response Scale (SRS);Gesell developmental schedule, GDS; | — |
Countries
China
Contacts
Public ContactXiuxia Wang
The Second Hospital of Hebei Medical University
Outcome results
None listed