functional dyspepsia
Conditions
Interventions
Group 1:3 pieces of duodenal bulb and 3 pieces of duodenal descending segment mucosa tissue were taken by gastroscope forceps
Group 2:3 pieces of duodenal bulb and 3 pieces of duodenal descending segment mucosal tissues from healthy volunteers were taken by gastroscope forceps
Sponsors
The Third People's Hospital of Chengdu
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years; 2. Meet the diagnostic criteria of Rome IV for functional dyspepsia: early satiety discomfort after meals, early satiety, epigastric pain, epigastric burning sensation, and no evidence of organic disease (including gastroscopy) that can explain the symptoms; Symptoms have appeared for at least 6 months before diagnosis, and the above criteria have been met in the past 3 months.
Exclusion criteria
Exclusion criteria: 1. Combined with peptic ulcer and other gastrointestinal organic diseases; 2. Severe dysplasia in gastric mucosa, or suspected malignant transformation in pathological diagnosis; 3. Pregnant or lactating women; 4. Obvious heart, lung, liver and kidney dysfunction; 5. Have a history of connective tissue disease, diabetes, or mental illness; 6. History of abdominal surgery; 7. Long-term continuous use of non-steroidal anti-inflammatory drugs; 8. Those who have lost more than 3 kg in weight in the near future.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of tight junction proteins genes;Protein expression of tight junction proteins; | — |
Countries
China
Contacts
Public ContactWu Liping
Department of Gastroenterology
Outcome results
None listed