ARDS
Conditions
Interventions
experimental group:Remazolam maintained sedation at 0.1 to 0.3 mg/kg/h, with the goal of achieving a RASS score of - 1 to 0.
control group:Midazolam maintains sedation (adjusted for age, weight, etc.) with a goal of achieving a RASS score of -1 to 0.
Sponsors
Second Affiliated Hospital of Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old; 2. Receive invasive mechanical ventilation; 3. It is expected that the extubation conditions cannot be achieved within 48 hours and the expected ICU hospitalization time is greater than 5 days; 4. Sedative drugs are required to ensure comfort, safety and facilitate the implementation of life support measures; 5. The subject or his authorized client gave informed consent and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pregnant women and babies; 2. Severe central nervous system disease, GCS less than 8 points (massive cerebral infarction/hemorrhage; status epilepticus; severe dementia, etc.); 3. Unstable angina or acute myocardial infarction, left ventricular ejection fraction <= 30%; 4. Heart rate < 50 bpm, type 2 second-degree or third-degree atrioventricular block (except for implanted pacemaker); 5. After adequate fluid resuscitation, use two vasoconstrictors to maintain SBP above 90 mmHg; 6. Alcohol or drug withdrawal, mental illness; 7. Hypersensitivity to benzodiazepines such as remimazolam and midazolam.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Arterial blood pressure;Heart rate;Respiratory rate;Confusion Assessment Method, CAM-ICU;The Richmond Agitation-Sedation Scale, RASS;Self-Rating Depression Scale, SDS; | — |
Primary
| Measure | Time frame |
|---|---|
| Duration of mechanical ventilation;EEG waveform changes during sedation maintenance; | — |
Countries
China
Contacts
Public ContactHuang Man
The Second Affiliated Hospital of Medical College of Zhejiang University
Outcome results
None listed