Capacity overload peritoneal dialysis patients
Conditions
Interventions
Tolvaptan group:Tolvaptan, 15 mg, QOD, orally every other day (both before and after meals), for a total of 6 months of conventional treatment.
control group:Routine treatment for a total of 6 months.
Sponsors
Department of Nephrology, the second hospital of Jilin University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Have serious behaviors (self harm, serious repetitive and stereotyped behaviors) or emotional problems (frequent emotional breakdown); 2. Have other disease diagnoses (e.g., visual impairment). 1. Age: 18-70 years; Regularly treat PD for = 1.7 orCcr>=50ml/min; 4. According to bioelectrical impedance measurement, excessive water (OH) >= 1.0L; 5. Have not taken vasopressin V2 receptor antagonists such as lovastatin in the past 3 months; There are no restrictions on natriuretic peptide preparations such as sarcubatrixartan, neobiotin, and traditional diuretics such as furosemide, spironolactone, etc; 6.The patient agreed to the study protocol and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Daily urine volume is greater than 1000ml or less than 100ml; 2. Combined hemodialysis; 3. Hypovolemic hyponatremia, hypernatremia; 4. Due to personal reasons, it is necessary to use it in combination with powerful CYP3A inhibitors (such as ketoconazole, etc.); 5. Complications associated with PD infection and catheter complications; 6. Patients with active infection, malignant tumor, chronic liver disease, and chronic obstructive pulmonary disease; 7. During pregnancy or lactation, women of reproductive age do not agree to use contraception during the trial; 8. Those who plan to undergo kidney transplantation surgery in the past 18 months; 9. Those who have poor compliance and cannot be treated according to the protocol. 10.Patients participating in other clinical trials
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Capacity load index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiac function index;Renal function index;General status of the patient;Biochemical detection; | — |
Countries
China
Contacts
Public ContactCui Wenpeng
The second hospital of Jilin University
Outcome results
None listed