endoscopy
Conditions
Interventions
Remimazolam group:Injective remimazolam
Esketamine group:Injective esketamine
Sponsors
Renmin Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. ASA I-III level; 2. Age between 65 to 80 years old; 3.BMI18~28; 4. Patients who plan to undergo endoscopy under general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Low blood volume, shock, or coma; 2. Uncontrolled hypertension (systolic blood pressure>180mmHg, diastolic blood pressure>110mmHg); 3. Coronary heart disease, cardiac insufficiency; 4. Have a history of mental system diseases and long-term use of psychotropic drugs; 5. Cerebrovascular diseases; 6. Serious arrhythmia; 7. People with cognitive impairment; 8. Those who are allergic to or contraindicated to the components of benzodiazepines and Esketamine drugs; 9. Have a history of drug dependence; 10. Have used other sedative drugs in the past week; 11. I have participated in clinical trials of drugs as a subject in the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sucess rate of sedation; | — |
Secondary
| Measure | Time frame |
|---|---|
| event time;Hemodynamic;respiration;Spo2;dose of medicine;adverse effect;awareness; | — |
Countries
China
Contacts
Public ContactZhongyuan Xia
Renmin Hospital of Wuhan University
Outcome results
None listed