lower respiratory tract infection
Conditions
Interventions
Gold Standard:Conventional controlled laboratory tests refer to the 2018 Infectious Diseases Society of America and American Society for Microbiology guidelines for laboratory diagnosis of infectious
Index test:Consistency of results between mNGS and traditional methods, sensitivity, specificity, negative/positive coincidence rate of each detection method
DDDs, duration of antibiotic, hospital stay, mortality of subjects in each group.
Sponsors
The First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Male or female, aged 18 years and above; 2. Judged as suspected lower respiratory tract infection, among which lower respiratory tract pneumonia includes hospital-acquired pneumonia, community-acquired pneumonia, invasive pulmonary mycosis, and bronchiectasis complicated by infection. The specific diagnostic criteria are listed in Appendix I. The diagnostic criteria of the disease refer to the corresponding guidelines. For hospital-acquired pneumonia, refer to the 2016 American Thoracic Society and Infectious Diseases Society Guidelines for the Diagnosis and Treatment of Hospital-Acquired Pneumonia, and for community-acquired pneumonia, refer to the 2019 guidelines. American Thoracic Society and Society of Infectious Diseases guidelines for the diagnosis and management of community-acquired pneumonia; invasive pulmonary mycosis with reference to the 2019 European Organization for Cancer Research and Treatment and Mycosis Study Group Education and Research Consortium (EORTC/MSG) Revision and update of the consensus definition of venereal mycosis; bronchiectasis and infection refer to the 2019 British Thoracic Society adult bronchiectasis guidelines; 3. Complete and complete clinical information; 4. Be able to communicate in language or writing, agree to participate in this study and sign informed consent, and be able to complete the test-related inspections.
Exclusion criteria
Exclusion criteria: 1. There are contraindications for tracheoscopy, such as blood coagulation dysfunction and platelet count below 50 * 10 ^ 9/L; 2. Known to be infected with human immunodeficiency virus or novel coronavirus; 3. Patients who cannot understand and implement the investigation plan; 4. Pregnant and lactating patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity of different mNGS techniques for pathogenic diagnosis of lower respiratory tract infection;The specificity of different mNGS techniques for the etiological diagnosis of lower respiratory tract infection; | — |
Secondary
| Measure | Time frame |
|---|---|
| defined daily dose of antibiotic;Course of antibiotics;Length of stay;Mortality rate;Positive Predictive Value;Negative Predictive Value; | — |
Countries
China
Contacts
Public ContactYe Feng
The First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed