Multiple System Atrophy
Conditions
Interventions
Test group:Huanshaodan derived prescription
Healthy control group:None
Sponsors
Dongfang Hospital of Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Test group: 1) Comply with the above MSA Western medicine diagnostic criteria; 2) Between the ages of 30 and 80; 2. Control group: 1) No history of neurological and psychiatric disorders; 2) No major complaints such as memory impairment, cognitive decline, and emotional impairment; 3) MMSE total score >= 27 points, MoCA greater than or equal to 26 points, total score >= HAMA total score<7 points, HAMD total score<7 points.
Exclusion criteria
Exclusion criteria: 1. Neurological examination indicates the presence of brain atrophy or dementia caused by systemic diseases or other clear causes, such as severe depression, cerebrovascular disease, poisoning, and metabolic diseases; 2. Significant slowing of vertical rapid scanning or vertical supranuclear gaze paralysis; 3. Evidence of local cortical damage, such as aphasia, hemiplegia, parietal lobe dysfunction, etc; 4. Complicated with serious diseases (such as heart, lung, liver, kidney, endocrine, blood and other system diseases); 5. Have blood borne infectious diseases (such as hepatitis B, syphilis, AIDS, etc.); Patients with significant aphasia, severe dysarthria, and other diseases that affect clinical evaluation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MSA TCM symptom Assessment Scale;Unified multisystem atrophy scale score,UMSARS;MSA-NMSS;Hamilton Anxiety Scale Score, HAMA;Hamilton Depression Scale Score, HAMD;Montreal Cognitive Assessment, MoCA;Mini-mental State Examination, MMSE;overactive bladder symptom scores, OABSS;MRI(T1,T2,Flair,T1W1);fMRI(BOLD,DTI);p-a-syn(blood,ODEs);Exosomes; | — |
Countries
China
Contacts
Public ContactChen ZhiGang
Outcome results
None listed