DOC patients after ischemic-hypoxic brain injury
Conditions
Interventions
Consciousness disorders group:None
Control group:None
Sponsors
Huashan Hospital,Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients with hypoxic ischemic encephalopathy (HIE): 1. Age >= 18 years old and= 2 months; 4. There is a disturbance of consciousness that has been assessed as vegetative or minimally conscious by the Coma Recovery Scale - Revised Edition; 5. FDG-PET brain imaging has been completed; 6. Right handedness before onset; The legal representative of the subject can understand and sign the informed consent form. Inclusion criteria for healthy subjects: 1. Age >= 18 years old and<80 years old, regardless of gender; 2. Previously in good health, I came to the PET Center of Huashan Hospital to undergo a full body FDG-PET scan for the purpose of physical examination; 3. Brain FDG-PET scanning has been completed; 4. Right handed; 5. The subject himself or her legal representative can understand and sign the informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients with hypoxic ischemic encephalopathy (HIE): 1. Have previously experienced diseases that cause brain parenchymal damage such as cerebrovascular diseases, brain trauma, intracranial tumors, and central nervous system neuritis; 2. Progressive deterioration of consciousness or new neurological deficits within 2 weeks before PET brain imaging; 3. Those who are participating in other clinical trials when performing PET brain imaging, or have participated in clinical trials of drugs or invasive treatment, or have participated in clinical trials of non-invasive treatment within 6 months before PET brain imaging; 4. When PET brain imaging is performed, there are serious systemic diseases, including but not limited to: acute coronary artery disease, heart failure, unstable angina or arrhythmia, uremia, liver failure, sudden stroke, acute myocardial infarction, unstable diabetes, uncontrolled chronic obstructive pulmonary disease, uncontrolled hypertension, uncontrolled epilepsy, sepsis or serious infectious diseases, Or a previous history of mental disorders and severe depression, or significant abnormalities in laboratory tests, clinically significant or unstable conditions, or a history of drug abuse or alcoholism; 5. Previous clinical conditions that the moderator of this study believes may have an impact or potential impact on the results of this study. Exclusion criteria for healthy subjects: 1. Have previously experienced diseases that cause brain parenchymal damage such as cerebrovascular diseases, brain trauma, intracranial tumors, and central nervous system neuritis; 2. Past serious systemic diseases, including but not limited to: acute coronary artery disease, heart failure, unstable angina or arrhythmia, uremia, liver failure, sudden stroke, acute myocardial infarction, unstable diabetes, uncontrolled chronic obstructive pulmonary disease, uncontrolled hypertension, uncontrolled epilepsy, sepsis or serious infectious diseases, Or has a previous history of mental disorders and severe depression, or has significant abnormalities in laboratory tests, clinically significant or unstable conditions, or a history of drug abuse or alcoholism; 3. The whole body FDG-PET scan reveals abnormalities in the nervous system or other organs that the moderator of this study believes may have an impact or potential impact on the results of this study; 4. During pregnancy or lactation; 5. The subject has other clinical conditions that the moderator of the study believes may have an impact or potential impact on the results of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Connors Behavior Rating Scale;PET-CT; | — |
Secondary
| Measure | Time frame |
|---|---|
| GCS score; | — |
Countries
China
Contacts
Public ContactHe Zhijie
Huashan Hospital, Fudan University
Outcome results
None listed