Parkinson's disease
Conditions
Interventions
1:Mediterranean diet
2:High Fibre Diet
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: (i) A diagnosis of idiopathic mild-to-moderate PD, as indicated by the Hoehn & Yahr Scale37 Stage I-III (presenting with mild-to-moderate unilateral/bilateral symptoms, some postural instability, physically independent); (ii) be aged =18 years; (iii) meet Rome III criteria for functional constipation38 (See Table 1 for the detailed diagnostic criteria); and (iv) be able to give written consent.
Exclusion criteria
Exclusion criteria: (i) Those currently on specific diet prescription/ use of probiotics; (ii) use of antibiotics within 6 weeks before the start of the study; (iii) any inflammatory bowel disease/previous GI tract surgery; (iv) significant cognitive impairment indicated by an Abbreviated Mental Test score =6 (sensitivity: 96%; specificity: 94%)39; (v) history of laxative abuse; (vi) other contraindication that may limit full participation (e.g., severe dysphagia); and/or (vii) allergic to one or more of the following: nuts, fish or olive oil.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of complete bowel movements; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gut microbiome composition;Health related quality of life;Dietary habits;PD-related motor and non-motor symptoms;Bowel movement;Stool consistency;Use of laxative; | — |
Countries
China
Contacts
Public ContactJojo Yan Yan Kwok
The University of Hong Kong
Outcome results
None listed