thyroid surgery
Conditions
Interventions
Normal saline group:When suturing of the subcutaneous layer begin,patients are given saline, first with a bolus of 0.5 mg/kg load, and then pumped at a speed of 0.05 mg/kg/h.
Remimazolam group:When suturing of the subcutaneous layer begin,patients are given ramazolam. Ramimazolam is prepared to 1 mg/ml, first bolus at a load of 0.5 mg/kg, and then pumped at a rate of 0.05
Dexmedetomidine group:When suturing of the subcutaneous layer begin,patients are given dexmedetomidine. Dexmedetomidine is formulated to 4 µg/ml and infused at a load of 0.5 µg/kg for more than 10 min
Sponsors
The Second Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients aged between 18 and 65 years old are scheduled to undergo thyroid surgery under general anesthesia and tracheal intubation; 2. Its BMI is 18.5-30kg/m2 and the American Association of Anesthesiologists (ASA) is Class I or II; 3. All patients and their families are informed and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Myasthenia gravis; 2. Existing upper respiratory tract infection; 3. Smoking, asthma and other airway hypersensitivity; 4. Use of angiotensin converting enzyme inhibitor (ACE-I), bronchodilator or steroid drugs; 5. Previous severe angina attack, arrhythmia, bradycardia or atrioventricular block, sick sinus syndrome; 6. Chronic renal failure and chronic liver damage; Chronic alcoholism and drug abuse; 7. It is difficult to pull out the pipe.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of cough during tracheal extubation;the severity of cough grade during tracheal extubation;total number of coughs during tracheal extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| time to awakening;time to extubation;hemodynamic changes; | — |
Countries
China
Contacts
Public ContactMingjian Kong
Xuzhou Medical University
Outcome results
None listed