sleep disorders
Conditions
Interventions
Group A:Stage one propofol, stage two Remazolam toluenesulfate for injection
Group B:Stage one, Remazolam toluenesulfate, stage two, propofol
Sponsors
Zhongnan Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. The subject's written informed consent has been obtained before conducting any examination, sampling, or analysis related to the study; 2. Aged 18~40 years; 3. ASA grading ?-?.
Exclusion criteria
Exclusion criteria: 1. Patients with sleep disorders; 2. Habitual short sleepers; 3. Patients with chronic pain disease and long-term use of sedative and analgesic drugs; 4. Patients who took sedative and analgesic drugs 24h before surgery; 5. Drug abusers, drug and alcohol addicts; 6. Patients with mental disorders, depression, dementia, neurological diseases, previous history of brain injury, craniotomy, or combined with cerebral aneurysm, cerebrovascular malformation, respiratory diseases, cardiovascular system diseases; 7. Previously known hepatic and renal insufficiency; 8. Patients with language disorders, vision and hearing disorders, unable to communicate with others, unable to take care of themselves, and unable to record sleep independently, such as patients with Alzheimer's disease; 9. Pregnancy; 10. Systolic blood pressure > 160 mmHg and/or diastolic blood pressure > 100 mmHg; Heart rate > 100bpm or 30; 12. Neck circumference > 40cm; 13. Night shift workers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sleep structure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total sleep time;Sleep efficiancy;Number of awakening;N2 proportion;N3 proportion;Pittsburgh sleep quality index;Urine levels of 6-hydroxymelatonin;Bispectral index; | — |
Countries
China
Contacts
Public ContactChen Ting
Zhongnan Hospital of Wuhan University
Outcome results
None listed