amyotrophic lateral sclerosis (ALS)
Conditions
Interventions
case series:None
Sponsors
The First Hospital of Yichang
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. ALS patients treated in the First People's Hospital of Yichang from April 2021 to April 2022; 2. Aged >=18 years; 3. Diagnosis of clinically positive, probable and probable ALS in accordance with the revised IE Escorial standards (1998); 4. Primidone (62.5-125 mg/day) was applied; 5. Informed consent for off-label drug use has been signed.
Exclusion criteria
Exclusion criteria: 1. Pregnant and lactating patients; 2. Creatinine clearance <50ml/min; 3. Diseases or injuries that interfere with functional evaluation or endanger life; 4. Any known motor neurone disease not associated with ALS; 5. Major mental illness, cognitive dysfunction; 6. History of localized inflammation or chronic systemic inflammation before taking medication; 7. Patients suffering from vision changes, diplopia, nystagmus, ataxia, porphyria, wheezing, chronic obstructive pulmonary disease or other respiratory diseases that may aggravate breathing difficulties or airway obstruction before taking medication; 8. The presence of major heart, kidney, liver or other systemic diseases; 9. Unwillingness or inability to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient Self-Assessment Questionnaire;Modified ALS Functional Score;ROADS Scale;CNS-BFS Scale;Forced vital capacity;Walking test; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum RIPK1 and RIPK3 levels;Inflammatory cytokin;Urine factor; | — |
Countries
China
Contacts
Public ContactZha Yunhong
The First Hospital of Yichang
Outcome results
None listed