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The improvement of aphasia after stroke in patients with chronic stroke undergoing neurotomy of C7 nerve at intervertebral foramen: An exploratory clinical trial

The improvement of aphasia after stroke in patients with chronic stroke undergoing neurotomy of C7 nerve at intervertebral foramen: An exploratory clinical trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200060147
Enrollment
Unknown
Registered
2022-05-20
Start date
2022-06-01
Completion date
Unknown
Last updated
2024-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

aphasia post-stroke

Interventions

Experimental group:Proximal foraminal seventh cervical nerve amputation + speech language rehabilitation

Sponsors

Jing'an District Central Hospital (Jing'an Branch of Huashan Hospital)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aphasia caused by cerebral infarction or hemorrhage, more than 6 months after onset; 2. Aged over 18 years, no gender limit, right-handed, native Chinese; 3. Aphasia was diagnosed by WAB with an aphasia quotient of less than 93.8; 4. Willingness to undergo cervicoseptal nerve amputation; 5. The consciousness, intelligence and language status can cooperate with the language rehabilitation training.

Exclusion criteria

Exclusion criteria: 1. Surgical contraindications for any reason judged by a qualified anesthesiologist or clinician, including but not limited to: serious untreated medical disease, severe cerebrovascular stenosis, etc.; 2. Recurrent acute bleeding or infarction; 3. Contraindications of MRI scanning; 4. Received intensive post-stroke rehabilitation treatment 4 weeks before enrollment.

Design outcomes

Primary

MeasureTime frame
Boston Naming Test;

Secondary

MeasureTime frame
Western Aphasia Battery Test;Ability to Communicate in Daily Life Scale;Upper-limb Fugl-Meyer Scale;Modified Ashworth Scale;

Countries

China

Contacts

Public ContactXu Wendong
wendongxu@fudan.edu.cn+86 21 61578012

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026