Pancreatic tumors, liver tumors, stomach and intestinal tumors
Conditions
Interventions
Remifentanil group:Remifentanil continuous infused with 0.2-0.5ug/kg/h
Low-opioid anesthesia group:Esketamine and dexmedetomidine continuous infused with 0.2-0.5ug/kg/h
Sponsors
Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective laparoscopic major abdominal surgery (laparoscopic pancreaticoduodenectomy, laparoscopic hepatectomy, laparoscopic gastrectomy and laparoscopic enterectomy); 2. Aged 18-65 years; 3. BMI: 18.5-28kg/m^2; 4. The operation time is more than 2 hours; 5. No serious systemic disease; 6. No history of drug allergy.
Exclusion criteria
Exclusion criteria: 1. Patients with distant metastasis and malignant tumors in other organs have received preoperative radiotherapy, chemotherapy or immunotherapy; 2. Patients with autoimmune diseases who have received glucocorticoid or immunosuppressive therapy within 1 year; 3. Severe liver disease, kidney failure or ASA grade IV or above; 4. History of major operation within 1 year; 5. Patients who used opioids before surgery; 6. Pregnant or lactating patients; 7. Long-term use of sedatives, analgesics, chronic alcoholism or drug abuse; 8. Patients with a history of mental illness, language communication disorder, hearing impairment, or inability to understand the test content.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative numeric rating scale pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Post-operative quality of recovery scale (PQRS);Postoperative Pittsburgh sleep quality index;Postoperative hospital duration;Complications;Relapse free survival and overall survival; | — |
Countries
China
Contacts
Public ContactZhong Min
Guangdong Provincial Hospital of Chinese Medicine
Outcome results
None listed