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High-risk factors for benign epilepsy in children with centrotemporal spikes to evolve into variants, and related research on constructing and validating their prediction models

High-risk factors for benign epilepsy in children with centrotemporal spikes to evolve into variants, and related research on constructing and validating their prediction models

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200060128
Enrollment
Unknown
Registered
2022-05-19
Start date
2022-05-08
Completion date
Unknown
Last updated
2024-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

benign epilepsy in children with centrotemporal spikes (BECTS)

Interventions

Case series:None

Sponsors

Children's Hospital of Chongqing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. The age of onset ranged from 2 to 18 years; 2. No neurological abnormalities or mental defects before the onset of the disease; 3. Sleep period mainly partial motor attacks, often accompanied by somatosensory symptoms; 4. Spinous foci were located in the central and temporal regions (Rolandic region), and the interparoxysmal background activity was normal; After a period of follow-up, children meeting any of the following conditions were enrolled in the BECTS variant group when they developed atypical symptoms or EEG: (1) New seizure types (negative myoclonus, atypical absence) and/or oropharyngeal dyskinesia occur during the course of the disease; (2) EEG showed that the localized discharge in the Rolandic region increased significantly in both awake and sleeping periods, and some of the discharge reached the ESES during sleep; (3) Cognitive impairment occurred after the onset of the disease (Wechsler intelligence screening), and patients who did not meet the above three criteria during the follow-up period were enrolled into the BECTS typical group.

Exclusion criteria

Exclusion criteria: Previously known neurological or psychiatric disorders, incomplete clinical data, and lost follow-up during follow-up.

Design outcomes

Primary

MeasureTime frame
Age of onset of epilepsy;Intermittent focal slow wave;Multiple asynchronous spike-slow wave lesions;Generalized 3Hz sharp slow wave discharge;

Countries

China

Contacts

Public ContactHu Qiao

Children's Hospital of Chongqing Medical University

qiaohu1989@163.com+86 15823994921

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026