gastrointestinal tumor
Conditions
Interventions
Group 1:Propofol-based total intravenous anesthesia
Group 2:Sevoflurane-based inhalation anesthesia
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 89 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 65 years and < 90 years; 2. Intended to undergo surgery for primary malignant tumors of the gastrointestinal system under general anesthesia, including surgery for malignant tumors of the esophagus, stomach, small intestine, colorectum and malignant tumors of the liver, bile and pancreas; 3. The expected duration of surgery exceeds 2 hours.
Exclusion criteria
Exclusion criteria: 1. Refuse to participate; 2. Emergency surgery; 3. Severe cardiac insufficiency (preoperative LVEF < 30% or NYHA class IV), severe hepatic failure (Child-Pugh class C), severe renal failure (receiving dialysis preoperatively), or ASA classification IV or higher; 4. Preoperative schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis; 5. Pre-operative inability to communicate due to coma, severe dementia or speech impairment; 6. Other reasons why the investigator believes the patient should not participate in this study, which must be clearly and detailed in the CRF.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total sleep time on the first postoperative night; | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma Orexin concentrations;Cognitive function score;The incidence of complications;Mortality;The total sleep time;Sleep quality;Sleep quality score; | — |
Countries
China
Contacts
Public ContactLi Huaijin
Peking University First Hospital
Outcome results
None listed