obstructive sleep apnea hypopnea syndrome
Conditions
Interventions
Group A:Before anesthesia induction, Nalbuphine hydrochloride injection 0.2mg/kg was injected intravenously, diluted to 5ml with sterile normal saline
Group B:Nalbuphine hydrochloride injection 0.2mg/kg was injected intravenously 10 minutes before the end of the operation, diluted to 5ml with sterile normal saline
Group C:None
Sponsors
The Children's Hospital of Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
4 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Clinical diagnosis of obstructive sleep apnea hypopnea syndrome (OSAHS), adenotonsillectomy is required; 2. Aged 4-12 years, gender is not limited, weight 10-40 Kg, BMI 14.0-28kg/m^2, ASA class I or II, surgery time 30-90 min; 3. The child's parent or legal guardian signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to nalbuphine hydrochloride or its components, children with a history of opioid allergy; 2. Analgesic sedatives, emetic drugs and antipruritus drugs were used 24 hours before surgery; 3. Patients with body temperature higher than 38? or symptoms of acute upper respiratory tract infection within 24h before surgery; 4. Renal function impairment (BUN and/or Cr> upper limit of normal); Liver function impairment (ALT and/or AST>1.5 times the upper limit of normal); 5. Patients with a history of severe head trauma and intracranial hypertension within 6 months; 6. Patients suffering from chronic neurological or mental diseases, or unable to express their wishes correctly; 7. Patients with a history of long-term sedative and analgesic drugs or monoamine oxidase inhibitors; 8. Accompanied by heart, blood, immune and other systemic diseases; 9. Patients with other conditions were not considered suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| steroids;inflammatory factors;blood glucose; | — |
Secondary
| Measure | Time frame |
|---|---|
| heart rate;blood pressure;FLACC Pain Score;Ramsay Sedation Score; | — |
Countries
China
Contacts
Public ContactCao Hongmin
The Children's Hospital of Zhejiang University School of Medicine
Outcome results
None listed