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Effects of Positive End-Expiratory Pressure on Cerebral Oxygenation and Hemodynamics in Patients Undergoing Thoracic Surgery during One-Lung Ventilation: A Randomized Crossover-Controlled Trial

Effects of Positive End-Expiratory Pressure on Cerebral Oxygenation and Hemodynamics in Patients Undergoing Thoracic Surgery during One-Lung Ventilation: A Randomized Crossover-Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200060112
Enrollment
Unknown
Registered
2022-05-19
Start date
2022-06-01
Completion date
Unknown
Last updated
2024-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intraoperative hypoxemia

Interventions

Group 1:PEEP: 0cmH2O, 5cmH2O, 10cmH2O
Group 2:PEEP: 0cmH2O, 10cmH2O, 5cmH2O
Group 3:PEEP: 5cmH2O, 0cmH2O, 10cmH2O
Group 4:PEEP: 5cmH2O, 10cmH2O, 0cmH2O
Group 5:PEEP: 10cmH2O, 0cmH2O, 5cmH2O
Group 6:PEEP: 10cmH2O, 5cmH2O, 0cmH2O

Sponsors

Qilu Hospital of Shandong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Aged between 60 and 80 years; 2. American Society of Anesthesiologists (ASA) physical class I-III.

Exclusion criteria

Exclusion criteria: 1. Severe cardiovascular and cerebrovascular diseases; 2. Severe liver and kidney dysfunction and coagulation dysfunction; 3. Diseases that cannot be monitored for cerebral oxygen saturation, such as head deformities and forehead skin infections; 4. Contraindications of radial artery puncture.

Design outcomes

Primary

MeasureTime frame
regional cerebral oxygen saturation;

Secondary

MeasureTime frame
hemodynamics;pulmonary oxygenation;

Countries

China

Contacts

Public ContactWu Jianbo
jianbowu@126.com+86 18560083793

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026