osteoporosis
Conditions
Interventions
Normal bone density without fracture group:none
Osteoporosis without fracture group:none
Osteoporosis with fracture group:none
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Postmenopausal women; 2. Normal bone density (T score >-1.5) at 3 sites (lumbar spine, total hip, and neck of femur), or osteoporosis at at least 1 of 3 sites (T score <= -2.5); 3. Volunteer and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Current antibiologic therapy or repeated antibiologic therapy within the past 6 months; 2. Current cortical therapy or discontinuation time less than 6 months; 3. Current treatment for osteoporosis or continued for more than 3 months in the past 5 years; 4. Current menopausal hormone therapy; 5. Current or discontinued drugs may affect bone metabolism (such as anti-aromatase); 6. Known liver, heart, or respiratory insufficiency; 7. Pathology that may affect bone metabolism, especially severe renal insufficiency; 8. Serious diseases, especially disabling and chronic diseases of the gastrointestinal tract; 9. Diseases characterized by severe diseases of the gut microbiome (e.g., severe obesity, BMI>40 kg/m^2, depression, poorly controlled diabetes); 10. Difficulties in communication or understanding due to mental illness or other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone density;Gastrointestinal microbiome; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bone metabolism index; | — |
Countries
China
Contacts
Public ContactYu Xijie
Outcome results
None listed