long-standing persistent atrial fibrillation
Conditions
Interventions
Experimental group:Circumpulmonary vein isolation (CVPI) and subsinusional stroma mapping for individualized ablation strategies
Control group:Circumferential pulmonary vein isolation + linear ablation
Sponsors
The First Affiliated Hospital with Nanjing Medical University (Jiangsu Province Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with symptomatic persistent atrial fibrillation who do not respond to treatment with at least one antiarrhythmic drug; 2. Aged 18-75 years; 3. Duration of atrial fibrillation >=1 year and less than 3 years; 4. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients who have previously received catheter ablation for atrial fibrillation; 2. Severe heart valve disease; 3. Severe structural heart disease; 4. Left atrial thrombosis; 5. Left atrial diameter (LAD) >55mm; 6. Platelet count 3 times the upper limit; Serum creatinine >3.5mg/dl or creatinine clearance <30ml/min); 10. Allergy to low molecular weight heparin, warfarin or new oral anticoagulants; 11. Life expectancy <1 year; 12. Pregnant and lactating patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of sinus rhythm maintenance within 1 year after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Perioperative serious complications (pericardial tamponade requiring surgical intervention, atrial esophageal fistula, stroke, pulmonary vein stenosis);The percentage of intraoperative spontaneous sinus cardioversion;The proportion of all ablation lines reached complete bidirectional block;Proportion of atrial tachycardia within 1 year after operation; | — |
Countries
China
Contacts
Public ContactZhang Fengxiang
The First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed