Clinical study of peak velocity variability of left ventricle outflow track in predicting fluid responsiveness in postoperative gerontal critically ill patients

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200059954

Enrollment

Unknown

Registered

2022-05-14

Start date

2022-05-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute circulatory failure

Interventions

Gold Standard:Fluid responsiveness was defined as an increase >10% in SV (measured by TTE) after PLR maneuver

Index test:The peak velocity variability of left ventricle outflow track by transthoracic doppler echocardiography

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. The elderly critically ill patients transferred to ICU after operation showed acute circulatory failure: 1) The systolic blood pressure is less than 90mmHg, and the average arterial pressure is less than 65mmHg (or needs to be maintained by norepinephrine); 2) Urine volume is less than 0.5ml/kg per hour and lasts more than 2 hours; 3) Lactic acid>2mmol/L; 4) Tachycardia, heart rate greater than 100 beats/min; 5) Skin mottling.

Exclusion criteria

Exclusion criteria: 1. Age<65 years; 2. Left ventricular (LV) dysfunction (ejection fraction<40%); 3. Intracranial hypertension; 4. Active bleeding; 5. Intra-abdominal hypertension; 6. Arrhythmias; 7. Lower limb disability; 8. Contraindications of PLR manipulation; 9. Echocardiogram cannot be obtained and the echo is not clear.

Design outcomes

Primary

Measure	Time frame
maximal peak velocity;minimal peak velocity;	—

Secondary

Measure	Time frame
mean arterial pressure;pulse pressure variation;stroke volume;central venous pressure;	—

Countries

China

Contacts

Public ContactJin Xie

The First Affiliated Hospital of Soochow University

xiejin728310@163.com+86 15806215256

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026