diabetic foot ulcers
Conditions
Interventions
0:VAC(vacuum-assisted closure)
1:control group (conventional moist dressings alginates)
Sponsors
Nanjing First Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with diabetes foot ulcer who meet the diagnostic criteria; 2. The age is between 20 and 80 years old; 3. diabetes foot ulcer, Wagner's grade is 2-3, and the course of disease is more than 2 weeks; 4. Ankle-brachial index (ABI) is 0.5-0.9; 5. The wound area of diabetes foot ulcer is 8-20cm2.
Exclusion criteria
Exclusion criteria: 1. Unable to cooperate to complete the follow-up; 2. Pregnant and lactating women; 3. Foot ulcer caused by other reasons (non diabetes); 4. Organ failure (heart failure, respiratory failure, liver failure, renal damage or intestinal failure); Patients with malignant tumors and hematological diseases; 5. Patients with peripheral vascular diseases or autoimmune diseases (rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, Sjogren's syndrome, connective tissue disease, systemic vasculitis); 6. Patients who have received local growth factor therapy or hyperbaric oxygen therapy in the past month; 7. Complicated with serious medical diseases, or used corticosteroids, immunosuppressants or chemotherapy drugs in the past 6 months; 8. Other conditions that the researcher thinks are not suitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| time from first debridement to STSG surgery ; | — |
Secondary
| Measure | Time frame |
|---|---|
| survival rates of skin graf;wound blood perfusion;Neutrophil extracellular traps;wound macrophages; | — |
Countries
China
Contacts
Public ContactWu Yin
Nanjing First Hospital
Outcome results
None listed