myocardial injury after noncardiac surgery
Conditions
Interventions
Personalized SBP Management Group:From the induction of ansthesia, continuous infusion of norepinephrine keeps SBP within ±10% of the baeseline.
General Management Group:When SBP is lower than 100mmHg, ephedrine or norepinephrine is given according to the anesthesiologist's personal preference.
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Aged over 60 years; 2.Plan to perform hip replacement surgery under general anesthesia; 3.A history of hypertension requiring medication and stratified cardiovascular risk factors with high risk or above.
Exclusion criteria
Exclusion criteria: 1. Long-term uncontrolled high blood pressure(SBP=180mmHg and/or DBP=110mmHg); 2. Secondary hypertension; 3. Acute or decompensated heart failure / acute coronary syndrome; 4. Severe arrhythmia/Severe valvular disease; 5. Preoperative sepsis; 6. Long-term chronic elevation of troponin; 7. Refused to participate; 8. To conduct another experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative myocardial injury; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of postoperative myocardial infarction;Incidence of postoperative acute renal injury;Length of stay at hospital;All-cause mortality 30 days after surgery;Cardiovascular outcomes 30 days after surgery;Incidence of systemic inflammatory response syndrome;Readmission rate;Vasoactive drug dosage;Incidence, frequency, and duration of intraoperative hypotension;Intraoperative blood pressure; | — |
Countries
China
Contacts
Public ContactJindong Liu
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed