Prostate cancer
Conditions
Interventions
Gold Standard:Histopathological examination of prostate biopsy
Index test:Urine DNA methylation and gene copy number variation were sequenced by WGBS.
Sponsors
PLA General Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age is equal to or greater than 18 years old and less than 90 years old when signing the informed consent form 2. Men with suspected prostate cancer as determined by elevated serum PSA level, positive digital rectum examination, and/or positive findings from imaging examinations, PSMA PET-CT/MR who plan to undergo prostate biopsy to confirm the diagnosis 3. Patients with prostate cancer diagnosed by prostate biopsy and planned to undergo radical prostatectomy, endocrine therapy or radiotherapy; 4. Patients undergoing regular PSA monitoring after radical prostatectomy; 5. Estimated survival > 12 months; 6. Consent and able to carry out follow-up visit and cooperate with all other study procedures.
Exclusion criteria
Exclusion criteria: 1. Severe disease or other medical conditions suggesting a high risk of death within 1 year, which may interfere with follow-up. Decided by investigator; 2. Prior transurethral enucleation resection of the prostateor Prostate radiotherapy; 3. Diagnosed with any other malignant tumor within 5 years before enrollment; 4. Unable to provide necessary follow-up information; 5. Other conditions that are judged as ineligible by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DNA methylation;gene copy number variation; | — |
Countries
China
Contacts
Public ContactXu Zhang
PLA General Hospital
Outcome results
None listed