Severe scoliosis
Conditions
Interventions
Trial group:Before suturing, use a medical irrigation gun (Chinese National Pharmaceutical Group) for irrigation. During the surgery, locally apply and inject 500mg of vancomycin hydrochloride (Stable
Control group:Before suturing, use a medical irrigation gun (China National Pharmaceutical Group) for irrigation. After irrigation, suture layer by layer according to the muscle layer, fascial layer,
Sponsors
Beijing Chaoyang Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age > 18 and 80 degree, supine position reverse bending flexibility < 30%; 3. Accept the first-stage operation of three-dimensional scoliosis correction + bone graft fusion + internal pedicle fixation; 4. Informed and agreed to participate in the experiment.
Exclusion criteria
Exclusion criteria: 1. History of spinal surgery or combined with other spinal and intraspinal lesions; 2. Experienced multiple growth rod adjustments; 3. In the perioperative period, combined respiratory tract (with symptoms such as coughing and expectoration), urinary tract infection (with frequent urination and urgency), and other system infections; 4. Combined with congenital heart disease, genetic disease, and other system diseases; 5. Combined with severe complications of surgery (neurological complications, bleeding, cerebrospinal fluid leakage); 6. Combining mental illness cannot cooperate with follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mean incidence of wound infection at one month after surgery;Incidence of any adverse reactions; | — |
Secondary
| Measure | Time frame |
|---|---|
| Abnormal rate of vital signs on the first day after surgery;Infection indicators;The compliance rate of vancomycin blood concentration in drainage fluid and blood;Functional scores(VAS,ODI,SF-36);Integration condition and local range of motion;Incidence of any adverse events and serious drug adverse reactions; | — |
Countries
China
Contacts
Public ContactPeng Yin
Beijing Chaoyang Hospital, Capital Medical University
Outcome results
None listed