General anesthesia
Conditions
Interventions
Control group:Standard monitoring guidance
Experimental group:qCON and qNOX monitoring guidance
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged > 18 years; 2. ASA I~III level; 3. Abdominal, urological, thoracic or orthopedic surgery performed under general anesthesia via laparoscopy or cesarean section; 4. Expected anesthesia time more than 60 min and postoperative transfer to PACU; 5. Consciously comply with the procedure of this experiment and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Non-elective surgery; 2. Intraspinal or any form of regional anesthesia is planned; 3. Preoperative acute or chronic pain, peripheral or central nervous system disorders, chronic opioid or non-opioid pain medications; 4. History of clearly diagnosed psychiatric disorders or other neurological or psychiatric conditions affecting the judgment of severe cognitive impairment, history of psychoactive drug use; 5. History of severe underlying disease (untreated or persistent peripheral or central cardiovascular disease, severe liver or kidney disease, severe pulmonary disease).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative opioid dosage;Perioperative cognitive function changes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total amount of propofol;Inflammation and stress level monitoring;Dosage of self-controlled analgesics;Hemodynamic fluctuations;Use of vasoactive drugs;Pain score;Postoperative delirium;Correlation between BIS values and qCON values;Time correlation between qCON values and qNOX values;Predictive ability of qCON and qNOX for recovery of consciousness;Speed of recovery of qCON versus qNOX after discontinuation of general anesthetics.;Monitoring ability and predictive power of qCON and qNOX for muscle relaxation and body movement;Correlation of qCON and qNOX with nociceptive stimuli;Time correlation of qNOX with opioids;Effect of beta-blocker use on qCON and qNOX;Effect of body temperature on qCON and qNOX;Factors influencing qCON and qNOX;Induction time of anesthesia;General anesthesia awakening time;Change of anxiety level;Change in sleep rhythm;Incidence of hypotension requiring treatment;Incidence of hypertension requiring treatment;Incidence of bradycardia requiring treatment;Incidence of tachycardia requiring treatment;Incidence of respiratory depression in PACU;Incidence of chills after awakening;Levels of frailty in old age correlate with altered cognitive function;Subject satisfaction;Researcher satisfaction; | — |
Countries
China
Contacts
Public ContactLi Yize
Tianjin Medical University General Hospital
Outcome results
None listed