Herpes zoster, Subacute Herpes Zoster Neuralgia
Conditions
Interventions
Amitriptyline group:Amitriptyline
ES-ketamine group:ES-ketamine
Control group:None
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 50 years old; 2. The effect of regular oral analgesics was ineffective, and the NRS score > 3; 3. Conformed to the diagnosis of subacute herpetic neuralgia (course of disease: 1-3 months); 4. If the affected nerves are the spinal nerves, and there is no abnormal MRI examination in the corresponding diseased segments; 5. No history of opioid abuse; 6. Be able to understand and complete the self-assessment scale; 7. Clearly understand the experimental process, voluntarily participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Accompanied by other neuropathic pain; 2. Complicated with severe cardiac, hepatic, pulmonary and renal insufficiency; 3. Coagulation dysfunction; 4. Suffering from mental illness and mental retardation; 5. Infection of puncture site; 6. Interruption of treatment due to electrode displacement, intractable cerebrospinal fluid leakage or nosocomial infection during electrical stimulation; 7. Allergy to test-related drugs or history of drug abuse; 8. Have participated in clinical trials of other drugs as subjects in recent 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Numerical rating scale;Self-rating anxiety scale;Self-rating depression scale;Pittsburgh sleep quality index, PSQI;Subjective sleep assessment;Overall satisfaction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Amitriptyline dosage;Dosage of duloxetine;Dosage of ketamine; | — |
Countries
China
Contacts
Public ContactJiang Xinghua
The Second Xiangya Hospital of Central South University
Outcome results
None listed