Major Depressive Disorder
Conditions
Interventions
A:Western medicine (Sertraline)
B:Western medicine (Sertraline) and Non-invasive TCM(Herbal medicine and auricular acupressure)
C:Western medicine (Sertraline) and Comprehensive TCM (Herbal medicine, auricular acupressure, and acupuncture)
Sponsors
Wushan County Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with mild or moderate depression by the relevant attending physician in reference to the International Classification of Diseases (ICD-10 F-32) [38] are recommended to a psychiatrist. Psychiatrists will evaluate the referred patients using HAMD-24 scores and divide patients into: Mild depression (8 35). Each group is randomly divided into Group A, B, and C; 2. Age of subjects: 18-60 years old. 3. Meet the criteria for diagnosis of depression, Hamilton Depression Scale (HAMD) 24 rating: 8-35 points. 4. Consented.
Exclusion criteria
Exclusion criteria: 1. Diagnosed with other severe organic diseases; 2. Terminally ill patients, including those with survival time less than 6 months, having severe organ function injury, unstable vital signs, and coma; 3. Concomitant other psychotic disorders and long-term consumption of psychotropic drug; 4. Acute suicidality; 5. Substance dependence; 6. Pregnant or lactating women, or fertile subjects who are not willing or unable to take effective contraceptive measures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton rating scale for depression (24-items) (HAMD-24);Treatment Emergent Symptom Scale, TESS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Family Burden Scale, FBS;36-Item Short Form Survey (SF-36);Beck Depression Inventory-II (BDI-II);Pittsburgh sleep quality index, PSQI; | — |
Countries
China
Contacts
Public ContactHan Yaosong
Wushan County Hospital of Traditional Chinese Medicine
Outcome results
None listed