Skip to content

A randomized controlled trial of granulocyte colony stimulating factor for the treatment of luteinized unruptured follicle syndrome

Study on the mechanism of G-CSF-mediated proinflammatory action in the occurrence and treatment of luteinized unruptured follicle syndrome

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200059797
Enrollment
Unknown
Registered
2022-05-11
Start date
2022-04-30
Completion date
Unknown
Last updated
2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

luteinized unruptured follicle syndrome

Interventions

Experimental group:G-CSF( 0.9 ml : 150 ug) is injected 24-48 hours prior to HCG administration
Control group:Inject placebo 0.9 ml (normal saline) 24-48 hours before using HCG

Sponsors

The Second Nanning People’s Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
22 Years to 39 Years

Inclusion criteria

Inclusion criteria: 1. The age of the patient is 22-39 years old, the menstrual cycle is normal, and the level of basic reproductive endocrine is normal; 2. Have not used non-steroidal drugs and contraceptives in the past six months, and have not received radiotherapy and chemotherapy; 3. The woman has a sound female reproductive tract structure and both fallopian tubes are unobstructed or at least one fallopian tube is unobstructed; 4. Both husband and wife voluntarily accept artificial insemination for assisted pregnancy, and sign an informed consent before the operation.

Exclusion criteria

Exclusion criteria: 1. Caused by factors such as hyperprolactinemia, abnormal thyroid function, pelvic local anatomy (such as moderate to severe endometriosis, pelvic inflammatory disease, pelvic surgery leading to ovarian surface adhesion, ovarian capsule thickening) and other factors Patients with LUFS; 2. White blood cell (WBC) count >= 10000 /ul at the time of administration; 3. Patients with serious diseases of liver, kidney and heart, and allergies.

Design outcomes

Primary

MeasureTime frame
The incidence of LUFS;

Secondary

MeasureTime frame
Clinical pregnancy rate;

Countries

China

Contacts

Public ContactLi Ning

The Second Nanning People’s Hospital

747190546@qq.com+86 15077182863

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026