Novel Coronavirus Pneumonia (COVID-19)
Conditions
Interventions
None listed
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged more than 18 years old and less than 70 years old; 2. General and severe hospitalized patients with SARS-CoV-2 confirmed by PCR, and the latest nucleic acid report sampling time before enrollment is within 48 hours; 3. Within 24 hours of admission; 4. Severely ill people with one or more of the following defined in this study: shortness of breath, RR >= 30 times/min; at rest, oxygen saturation <= 93% when inhaling air; arterial partial pressure of oxygen (PaO2) / Oxygen absorption concentration (FiO2) <= 300mmHg (1mmHg=0.133kPa); in high altitude (over 1000 meters above sea level) areas, PaO2/FiO2 should be corrected according to the following formula: PaO2/FiO2 x (760/atmospheric pressure (mmHg)). The clinical symptoms were progressively worsened, and the lung imaging showed that the lesions progressed more than 50% within 24 to 48 hours; 5. The patient is fully informed, agrees to participate in this trial and expects to complete the treatment and examination related to this trial.
Exclusion criteria
Exclusion criteria: 1. Have a history of COVID-19 infection in the past; 2. Need respiratory support (oxygen inhalation, non-invasive ventilator, etc.); 3. Receiving dialysis or known moderate to severe renal impairment (ie, EGFR < 45 ml/min/1.73 square meters within 6 months); 4. Poor compliance, unwilling to accept examinations or unwilling to complete follow-up; 5. Expect or have participated in other clinical trials; 6. Nursing or pregnant women; 7. Those with limited mobility or unresponsiveness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| exhaled viral load;3D-X-ray of the lungs; | — |
Countries
China
Contacts
Public ContactRen Tao
Shanghai Sixth People's Hospital
Outcome results
None listed