Hemodialysis patients with severe COVID-19
Conditions
Interventions
Group 1 :CRRT
Group 2:CRRT combined with Cytokine Adsorption
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Hemodialysis patients aged >= 18 years; 2. Meet the definition of severe or critical new coronary pneumonia in the Ninth Edition of the National Health and Family Planning Commission's New Coronary Pneumonia Diagnosis and Treatment Guidelines; 3. Have received standard treatment including fluid resuscitation, vasoactive drugs, antibiotics, respiratory support, nutritional support, and vital sign monitoring (in accordance with the 2021 SSCM guidelines); 4. Patients and their families are informed, voluntarily participate in this study, and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who are pregnant or suspected to be pregnant or breastfeeding at the time of enrollment; 2. Patients with extensive metastasis of malignant tumors; 3. Acute myocardial infarction in the past 4 weeks; 4. Combined with uncontrolled bleeding (acute bleeding > 3 UPC in the past 24 hours); 5. Patients with severe leukopenia (< 0.5 x 10^9/L) or severe thrombocytopenia (< 50 x 10^9/L); 6. Patients who are allergic to hemoperfusion devices and filters; 7. Those who are allergic to anticoagulants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All-cause Mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory factor clearance rate;Mean arterial pressure;Dosage of vasoactive drugs;Sequential Organ Failure Assessment Score;Length of ICU Stay;Kidney function recovery;Sequential Organ Failure Assessment Score;Duration of vasoactive drug use;Duration of mechanical ventilation; | — |
Countries
China
Contacts
Public ContactWang Niansong
Shanghai Sixth People's Hospital
Outcome results
None listed