Anesthesia for VATS lung resection
Conditions
Interventions
Experimental group:Balanced anesthesia with esketamine, dexmedetomidine, and sevoflurane
Control group:Balanced anesthesia with sufentanil and sevoflurane
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old; 2. American Association of Anesthesiologists (ASA) physical condition I-III; 3. Body mass index (BMI) is 18-30 kg/m2; 4. Planned elective VATS pneumonectomy.
Exclusion criteria
Exclusion criteria: 1. Sick sinus syndrome or severe bradycardia (heart rate < 50 beats/min); 2. More than second degree atrioventricular block without pacemaker; 3. Left ventricular ejection fraction < 40%; 4. History of coronary heart disease or myocardial infarction; 5. Liver or renal insufficiency (Child-Pugh C grade or undergoing renal replacement therapy); 6. Parkinson's disease or Alzheimer's disease; 7. Seizure or epilepsy; 8. Pregnancy or breastfeeding; 9. Have a history of chronic pain or use sedatives and analgesics before operation; 10. Allergic to the drugs in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of post-operative nausea and vomiting; | — |
Secondary
| Measure | Time frame |
|---|---|
| nausea;vomiting;need for antiemetic therapy;pain scores at rest and while coughing;postoperative sufentanil consumption;need for rescue analgesia;length of PACU stay;length of postoperative hospital stay;post-surgical pain in the follow-up;mortality in the follow-up; | — |
Countries
China
Contacts
Public ContactPeng Ke
The First Affiliated Hospital of Soochow University
Outcome results
None listed