elderly patients
Conditions
Interventions
Group P:Intravenous infusion of propofol
Group R:Intravenous infusion of remimazolam
Sponsors
Jiangsu Province Hospital
Eligibility
Sex/Gender
Male
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective urethral minimally invasive urological surgery under general anesthesia in Jiangsu Provincial People's Hospital from 2022.03 to 2022.08; 2. aged 65 to 80 years with ASA grade I-III; 3. BMI 19-25 kg/m^2.
Exclusion criteria
Exclusion criteria: 1. Patients with abnormal liver function (AST or ALT>2.5×ULN), has a medical history of hepatectomy or liver transplation; 2. Patients with abnormal renal function (serum creatinine>2 mg/dl); 3. Patients was assessed as having difficulty airway or difficulty mask ventilation; 4. Patients with serious cardiovascular disease, including uncontrolled hypertension (Systolic blood pressure is greater than 180 mmHg), atrioventricular block of grade 2 or higher, sick sinus syndrome, myocardial infarction or ventricular aneurysm; 5. Long-term use of sedatives, sleeping pills and antidepressants; 6. Allergic to study drugs (remimazolam, propofol, etc.); 7. Mental retardation mental disorders epilepsy, severe hearing, visual impairment, or any other conditions that affect would communication; 8. Chronic alcoholics or recent history of heavy drinking.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LVEF;SV;CO;LVOT-VTI;CI;SVRI;heart rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| E/A;e’;E/e’;SVR;SVRI;IBP;The amount of time from the use of the study drug to loss of consciousness;The amount of time from drug withdrawal to eye opening;The amount of time from drug withdrawal to extubation;The amount of time from drug withdrawal to the time when meet the standards for leaving the operating room;intraoperative awareness;injection pain;PONV;postoperative delirium; | — |
Countries
China
Contacts
Public ContactHe Mingfeng
Jiangsu Province Hospital
Outcome results
None listed