Acute Stanford type A aortic dissection
Conditions
Interventions
Control Group:Intratracheal injection of normal saline
Experimental group:Intratracheal injection of lidocaine
Sponsors
The Second Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Comply with the guidelines for the diagnosis and treatment of thoracic aortic disease (TAD) jointly issued by ACC/AHA in 2010, within two weeks after the onset; 2. The patients diagnosed as ATAAD by multi-slice spiral CT and color Doppler ultrasound and planned to undergo emergency surgery, including ascending aortic replacement (AAR), total arch replacement (TAR) and elephant trunk stent; 3. Age: 18-70 years old; 4. Weight: 50kg~100kg; 5. Volunteer to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Allergic to lidocaine; 2. Plenty of pericardial effusion and pleural effusion existed before operation; 3. There are factors of airway obstruction before operation, such as continuous bleeding or large amount of sputum; 4. Patients with stroke or spinal cord injury; 5. Previous cardiorespiratory diseases (such as intracardiac shunt, lung cancer, emphysema, pulmonary tuberculosis, COPD, bronchiectasis, etc.), nervous system diseases, hematological system diseases, liver and kidney insufficiency, connective tissue diseases, infection and thrombotic diseases, etc; 6. Severe cardiac insufficiency (LVEF<45%); 7. Pulmonary hypertension; 8. Patients take non-steroidal anti-inflammatory drugs or corticosteroids; 9. Previous cardiac and chest surgery; 10. BMI = 20 kg/m2 or = 30 kg/m2.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of hypoxemia 6 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intrapulmonary shunt;Four inflammatory response indicators;Three myocardial infarction indicators;Postoperative extubation time;Cardiac surgery intensive care unit stay time;Major adverse cardiovascular events; | — |
Countries
China
Contacts
Public ContactYanwu Jin
The Second Hospital of Shandong University
Outcome results
None listed