Depression
Conditions
Interventions
The experimental group:Use 0.25mg/kg ESM ketamine injection and physiological test Dilute saline injection to 50ml and drip intravenously for 40 minutes
The control group:Quetiapine fumarate (SRI Kang) was used as a synergist at a dose of 25-400 mg per day
Sponsors
Beijing Chaoyang Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Depression without psychotic symptoms is clinically diagnosed by a psychiatrist and meets the diagnostic criteria for depression without psychotic symptoms in DSM-IV; 2. The total score of the Montgomery-Ashelberg Depression Rating Scale (MARDS) is >= 22 points, and the suicide item score is >= 1 point, but they do not accept the recommendation of referral to the psychiatric hospital, and still require treatment at the study site; 3. Age 18-64 years old, gender unlimited; 4. Be able to understand the content of the scale and cooperate with the evaluation; 5. Sign the informed consent for the study and be able to follow up.
Exclusion criteria
Exclusion criteria: 1. Patients who have a history of alcohol dependence and acute poisoning in the past; Have a history of illegal drug abuse; Patients with psychotic disorder, bipolar disorder and obsessive-compulsive disorder; 2. At present, the main diagnosis is not depression; 3. Persons with high suicide risk at present: such as suicide attempts, who have attempted suicide recently; No family caregivers; 4. Female patients during pregnancy or lactation; 5. Do not use ketamine, Esketamine, or midazolam; 6. Patients who have used ECT or NMDA receptor antagonists in the last 6 months; 7. At present, there are patients with respiratory system diseases, hypertension, or other serious physical diseases that are difficult to control, such as severe cardiovascular diseases and hyperthyroidism, and patients with intracranial hypertension, intracerebral hemorrhage and glaucoma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montgomery-Asberg depression rating scale;Scale for Suicide Ideation;The Brief Psychiatric Rating Scale;Young manic rating scale;The Clinician Administered Dissociative States Scale;Quick Inventory of Depressive Symptomatology Self-Report;Frequency and Intensity of Side Effects Rating/Global Rating of Side Effects Burden, FISER/GRSEB;Patient Rated Inventory of Side Effects; | — |
Countries
China
Contacts
Public ContactHu Yongdong
Beijing Chaoyang Hospital
Outcome results
None listed