Anesthesia for thyroid and parathyroid surgery
Conditions
Interventions
Opioid-free anesthesia (OFA):Esketamine, lidocaine, dexmedetomidine, and propofol
Opioid-based anesthesia (OA):Sufentanil and propofol
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age = 18 years; 2. ASA classification I~III; 3. Thyroid and parathyroid surgery under selective general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Goiter causes tracheal compression or dyspnea; 2. Hyperthyroidism or hypothyroidism; 3. Obstructive sleep apnea syndrome; 4. Left ventricular ejection fraction<40%, second degree or more atrioventricular block, sick sinus syndrome, or severe bradycardia (heart rate [HR]<50 beats/min); 5. Severe hepatic and renal insufficiency (Child Pugh C grade or renal replacement therapy required); 6. Convulsions or seizures; 7. Chronic pain or use sedatives and analgesics before operation; 8. Allergy to any drug used in this study; 9. Pregnancy or lactation; 10. Unable to communicate before operation.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| the severity of PONV;antiemetic rescue therapy;pain scores at rest and while coughing;need for rescue analgesia;adverse effects related to anesthetics or analgesics (hypotension, bradycardia, desaturation, dizziness, headache, hallucination, and nightmare);time to extubation;length of PACU stay;length of postoperative hospital stay;patient satisfaction;a composite variable of 30-day major adverse events (myocardial infarction, cardiac arrest, cerebrovascular accident, coma, acute renal failure, pulmonary embolism, sepsis, septic shock, deep neck space infection, reintubation, reoperation, blood transfusion, failure to wean off ventilator, and death); | — |
Primary
| Measure | Time frame |
|---|---|
| incidence of postoperative nausea and vomiting (PONV); | — |
Countries
China
Contacts
Public ContactPeng Ke
The First Affiliated Hospital of Soochow University?
Outcome results
None listed