reflux esophagitis
Conditions
Interventions
Sponsors
The First Hospital of Nanchang
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Agree to accept esomeprazole treatment, have not received PPI before or stop PPI treatment for at least 1 month, aged 18-65 years; 2. Patients who have not taken antibiotics, probiotics, lactulose, other antacids or drugs that increase gastrointestinal motility or have received enema; 3. Liver and kidney functions are normal.
Exclusion criteria
Exclusion criteria: 1. Liver cirrhosis, kidney damage, tumor, thyroid disease, diabetes, Crohn's disease or ulcerative colitis; 2. Diarrhea, malabsorption and constipation caused by hiatal hernia, esophageal stricture, liver, gallbladder and pancreatic diseases; 3. History of gastrointestinal or abdominal surgery; 4. Pregnant or lactating women; Patients receiving immunosuppressive therapy; 6. Patients diagnosed as irritable bowel syndrome (IBS) according to RomeIII criteria, or patients who do not meet the diagnostic criteria but have persistent abdominal distension, diarrhea or constipation within = 3 months; 7. Severe cardiopulmonary insufficiency, significantly abnormal bleeding and clotting time (PT, APTT); 8. Those who cannot take orally or are allergic to probiotics; 9. The researcher believes that it is not suitable to participate in the clinical trial; 10. Those who have participated in clinical research of other drugs in the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical symptoms;Endoscopy;Inflammatory cytokines;Intestinal microecological analysis; | — |
Countries
China
Contacts
Public ContactNian Fan
The First Hospital of Nanchang
Outcome results
None listed