acute coronary syndrome (ACS)
Conditions
Interventions
Gold Standard:Diagnostic criteria for acute coronary syndrome.
Index test:GDF-15 combined with traditional cardiovascular markers cTnT, D-dimer, NT-proBNP and CK-MB were used for the diagnosis and differential diagnosis of acute coronary syndrome
Sponsors
The General Hospital of the People's Liberation Army
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.ACS group: (1) Aged >=18 years; (2) Suspected or confirmed ACS patients according to the guidelines for rapid Emergency Diagnosis and Treatment of acute coronary Syndrome (2019); (3) Meeting ACS diagnostic criteria; (4) Agree and sign informed consent. 2. Non-ACS group: (1) Aged >=18 years; (2) Patients with acute chest pain and exclusion of acute coronary syndrome, such as the diagnosis of major arterial dissection (AD) according to the Chinese Expert Consensus on the diagnosis and Treatment of aortic dissection (2017 edition); Acute pulmonary thromboembolism (PTE) was diagnosed according to the European Society of Cardiology Guidelines for the Diagnosis and Treatment of Acute pulmonary thromboembolism (2019 edition); (3) Meeting the diagnostic criteria for aortic dissection; (4) Meet the diagnostic criteria for acute pulmonary embolism; (5) Agree and sign informed consent. 3. Other unidentified patients with acute chest pain: (1) Aged >=18 years; (2) Agree and sign the informed consent. 4. Healthy control group: (1) Aged >=18 years; (2) No history of cardiovascular disease; (3) Agree and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Recent history of surgery and intracranial hemorrhage; 2. Complicated with malignant tumor; 3. A history of diabetes; 4. Fever, acute or chronic inflammatory diseases in the past 2 months; 5. Patients with blood disorders, coagulation disorders and autoimmune diseases; 6. Accompanied by liver and kidney dysfunction, infectious diseases; 7. Congenital cardiovascular system diseases, cardiogenic shock, serious heart failure, etc.; 8. Systolic blood pressure >=180 mmHg and failure to take antihypertensive drugs on time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Growth Differentiation Factor15;Cardiac Troponin T;D-Dimmer;NT-pro Brain Natriuretic Peptide; | — |
Secondary
| Measure | Time frame |
|---|---|
| Creatine Phosphokinase Isoenzyme;Blood Glucose;Ultrasound Cardiogram;CT Pulmonary Arteriography;Electrocardiogram; | — |
Countries
China
Contacts
Public ContactZhu Haiyan
The General Hospital of the People's Liberation Army
Outcome results
None listed