Acute kidney injury after partial nephrectomy
Conditions
Interventions
Intervention Group:Dexmedetomidine administration
Control Group:Normal saline administration
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. Undergo partial nephrectomy; 3. Prior to surgery, it is planned to perform renal artery occlusion during surgery; 4. Patient-controlled intravenous analgesia was used after surgery; 5. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2. Preoperative glomerular filtration rate< 45 ml/min/1.73 m^2; 3. Patients who have received kidney transplantation; 4. Preoperative LVEF< 30%, sick sinus syndrome, severe sinus bradycardia (heart rate< 50 beats/min), atrioventricular block above grade II without a pacemaker implant; 5. Allergic to the study drug.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute kidney injury within postoperative 48 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum cystatin C on the first and second postoperative day;Glomerular filtration rate of 6 months after surgery;Complications within postoperative 30 days; | — |
Countries
China
Contacts
Public ContactKong Hao
Peking University First Hospital
Outcome results
None listed